Vaccine third doses for people with immune problems
When it came to the coronavirus vaccine, she sought a third dose after two doses of the Pfizer-BioNTech vaccine failed to stimulate her immune system into creating antibodies, this time the Moderna injection. It was successful. A decent antibody response was observed in blood testing. However, it was lower than what would be found in healthy people. 
Last month, she received the fourth treatment with the aim of increasing her levels even higher. Jones underwent a kidney transplant in 2010 at the age of 45. She’s been taking immune-suppressing medicines to prevent the organ from being rejected since then. She expected to have a hard time reacting to a coronavirus vaccine, so she signed up for one of the only trials to date looking into the effectiveness of the third dosage in patients with weakened immune systems.
Dr Dorry Segev, a transplant surgeon at Johns Hopkins University who conducted the study, described being vulnerable to infection even after inoculation as “extremely worrisome and frustrating” for immunocompromised people. “Until we discover out a method to give kids stronger immunity, they have to behave unvaccinated.”‘
Immunocompromised people account for around 5% of the population. Some malignancies, organ transplants, chronic liver disease, kidney failure and dialysis, and medications including Rituxan, steroids, and methotrexate, used by about 5 million individuals for conditions ranging from rheumatoid arthritis and psoriasis to cancer, are among the reasons.
Not everyone is affected if they have one of these risk factors. However, without more research, it’s impossible to say who could require more vaccine doses and how many. Apart from the threat posed by COVID-19, there is evidence that inadequate immunity allows the virus to reproduce in the body for lengthy periods, perhaps leading to the emergence of new varieties.
